MicroRNA-Attenuated Virus Vaccines

MicroRNA-Attenuated Virus Vaccines

Blog Article

Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses.However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines.The use of host-derived microRNAs (miRNAs) to attenuate read more viruses has been accomplished in an array of biological contexts.The broad assortment of effective tissue- and species-specific miRNAs, and the ability to target a virus with multiple miRNAs, allow for targeting to be tailored to the virus of interest.

While escape is always a concern, effective strategies have been developed to improve the safety and stability of miRNA-attenuated viruses.In this review, we discuss the various 2000 bmw 528i front bumper approaches that have been used to engineer miRNA-attenuated viruses, the steps that have been taken to improve their safety, and the potential use of these viruses as vaccines.